Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4314222..4314738 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag CFU2785_RS21435 Protein ID WP_003839578.1
Coordinates 4314222..4314506 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CFU2785_RS21440 Protein ID WP_134216310.1
Coordinates 4314496..4314738 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS21420 4310547..4311131 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
CFU2785_RS21425 4311509..4313647 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
CFU2785_RS21430 4313754..4314218 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CFU2785_RS21435 4314222..4314506 - 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFU2785_RS21440 4314496..4314738 - 243 WP_134216310.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CFU2785_RS21445 4314816..4316729 - 1914 WP_134216312.1 BglG family transcription antiterminator -
CFU2785_RS21450 4316751..4317491 - 741 WP_048216922.1 KDGP aldolase family protein -
CFU2785_RS21455 4317488..4318606 - 1119 WP_003025770.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CFU2785_RS21460 4318590..4319723 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T292860 WP_003839578.1 NZ_LS992183:c4314506-4314222 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8963.38 Da        Isoelectric Point: 5.0649

>AT292860 WP_134216310.1 NZ_LS992183:c4314738-4314496 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPSEAVRLLFQYVAETGRMPVKTVTVSDCEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure

References