Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4245200..4245921 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag CFU2785_RS21095 Protein ID WP_063149808.1
Coordinates 4245200..4245541 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CFU2785_RS21100 Protein ID WP_080460847.1
Coordinates 4245577..4245921 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS21065 4241216..4241578 + 363 WP_003837149.1 endoribonuclease SymE -
CFU2785_RS21070 4241737..4242609 + 873 WP_134216258.1 HNH endonuclease -
CFU2785_RS21075 4242738..4243532 - 795 WP_134216261.1 helix-turn-helix transcriptional regulator -
CFU2785_RS21080 4243648..4243923 - 276 WP_063149810.1 type II toxin-antitoxin system RelE/ParE family toxin -
CFU2785_RS21085 4243927..4244175 - 249 WP_000535213.1 ribbon-helix-helix domain-containing protein -
CFU2785_RS21090 4244252..4245085 - 834 WP_063149809.1 DUF4942 domain-containing protein -
CFU2785_RS21095 4245200..4245541 - 342 WP_063149808.1 TA system toxin CbtA family protein Toxin
CFU2785_RS21100 4245577..4245921 - 345 WP_080460847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CFU2785_RS21105 4245945..4246166 - 222 WP_063149807.1 DUF987 family protein -
CFU2785_RS21110 4246114..4246650 - 537 WP_080460846.1 DNA repair protein RadC -
CFU2785_RS21115 4246720..4247538 - 819 WP_172616074.1 DUF945 domain-containing protein -
CFU2785_RS21120 4247678..4247929 - 252 WP_063149806.1 DUF905 family protein -
CFU2785_RS21125 4247926..4248597 - 672 WP_063149805.1 hypothetical protein -
CFU2785_RS26325 4248780..4249169 - 390 WP_063149804.1 hypothetical protein -
CFU2785_RS26330 4249181..4249888 - 708 Protein_4036 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(14-113)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12865.79 Da        Isoelectric Point: 9.8519

>T292859 WP_063149808.1 NZ_LS992183:c4245541-4245200 [Citrobacter freundii]
MKAFPATNQRVAKPCPSPVAVWQMLLTRLLAQHYGLTLNDTPFNDESVIQEHINAGITLADAVNFLVEKNELVRIDRRGF
SWQEQSPYLRAVDILRARQATGLLRQSHNLLTR

Download         Length: 342 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13074.13 Da        Isoelectric Point: 8.7074

>AT292859 WP_080460847.1 NZ_LS992183:c4245921-4245577 [Citrobacter freundii]
MKKDTANEVMDTLQWGLKCDITPHFGARLAQEGNRLHYLADRASIIGQFSKADLRHLNQAFPLLMKHMELMLTSGELNPR
HQHRVTLYAKRLTCEVDTLGSCGYVYIAIYPTQR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References