Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4243648..4244175 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CFU2785_RS21080 Protein ID WP_063149810.1
Coordinates 4243648..4243923 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A941UEC5
Locus tag CFU2785_RS21085 Protein ID WP_000535213.1
Coordinates 4243927..4244175 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS21060 4239067..4240437 - 1371 WP_003837154.1 tyrosine phenol-lyase -
CFU2785_RS21065 4241216..4241578 + 363 WP_003837149.1 endoribonuclease SymE -
CFU2785_RS21070 4241737..4242609 + 873 WP_134216258.1 HNH endonuclease -
CFU2785_RS21075 4242738..4243532 - 795 WP_134216261.1 helix-turn-helix transcriptional regulator -
CFU2785_RS21080 4243648..4243923 - 276 WP_063149810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFU2785_RS21085 4243927..4244175 - 249 WP_000535213.1 ribbon-helix-helix domain-containing protein Antitoxin
CFU2785_RS21090 4244252..4245085 - 834 WP_063149809.1 DUF4942 domain-containing protein -
CFU2785_RS21095 4245200..4245541 - 342 WP_063149808.1 TA system toxin CbtA family protein -
CFU2785_RS21100 4245577..4245921 - 345 WP_080460847.1 type IV toxin-antitoxin system YeeU family antitoxin -
CFU2785_RS21105 4245945..4246166 - 222 WP_063149807.1 DUF987 family protein -
CFU2785_RS21110 4246114..4246650 - 537 WP_080460846.1 DNA repair protein RadC -
CFU2785_RS21115 4246720..4247538 - 819 WP_172616074.1 DUF945 domain-containing protein -
CFU2785_RS21120 4247678..4247929 - 252 WP_063149806.1 DUF905 family protein -
CFU2785_RS21125 4247926..4248597 - 672 WP_063149805.1 hypothetical protein -
CFU2785_RS26325 4248780..4249169 - 390 WP_063149804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10942.30 Da        Isoelectric Point: 5.1546

>T292858 WP_063149810.1 NZ_LS992183:c4243923-4243648 [Citrobacter freundii]
MEVYWTLKAQDDLERIYRFALQYSRQHADDVLDGLITGCAGLKAHPAIGVQQTRYEPREVRKVLFDNYEVHYELRENDIY
IVDLWHTKEER

Download         Length: 276 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9004.31 Da        Isoelectric Point: 7.2042

>AT292858 WP_000535213.1 NZ_LS992183:c4244175-4243927 [Citrobacter freundii]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSDMVDFANRLK
KS

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References