Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2397945..2398584 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name hicA Uniprot ID A0A8B5QF36
Locus tag CFU2785_RS11875 Protein ID WP_003020221.1
Coordinates 2397945..2398121 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CFU2785_RS11880 Protein ID WP_123924900.1
Coordinates 2398168..2398584 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS11855 2394723..2394953 - 231 WP_003020233.1 DUF2554 family protein -
CFU2785_RS11860 2395143..2395268 - 126 WP_003020230.1 DUF2474 domain-containing protein -
CFU2785_RS11865 2395268..2396278 - 1011 WP_003020227.1 cytochrome d ubiquinol oxidase subunit II -
CFU2785_RS11870 2396278..2397681 - 1404 WP_003020224.1 cytochrome ubiquinol oxidase subunit I -
CFU2785_RS11875 2397945..2398121 + 177 WP_003020221.1 type II toxin-antitoxin system HicA family toxin Toxin
CFU2785_RS11880 2398168..2398584 + 417 WP_123924900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CFU2785_RS11885 2398677..2400086 + 1410 WP_134215520.1 PLP-dependent aminotransferase family protein -
CFU2785_RS11890 2400415..2401560 + 1146 WP_134215522.1 ABC transporter substrate-binding protein -
CFU2785_RS11895 2401577..2402593 + 1017 WP_058842662.1 ABC transporter ATP-binding protein -
CFU2785_RS11900 2402594..2403538 + 945 WP_003843727.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6769.80 Da        Isoelectric Point: 11.2510

>T292855 WP_003020221.1 NZ_LS992183:2397945-2398121 [Citrobacter freundii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 4.5716

>AT292855 WP_123924900.1 NZ_LS992183:2398168-2398584 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5QF36

Antitoxin

Source ID Structure

References