Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 920902..921556 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag CFU2785_RS04620 Protein ID WP_003026936.1
Coordinates 921149..921556 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag CFU2785_RS04615 Protein ID WP_003026938.1
Coordinates 920902..921168 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS04590 916103..917536 - 1434 WP_003838263.1 6-phospho-beta-glucosidase BglA -
CFU2785_RS04595 917657..918385 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
CFU2785_RS04600 918438..918749 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
CFU2785_RS04605 918912..919571 + 660 WP_003838267.1 hemolysin III family protein -
CFU2785_RS04610 919665..920645 - 981 WP_003838269.1 tRNA-modifying protein YgfZ -
CFU2785_RS04615 920902..921168 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
CFU2785_RS04620 921149..921556 + 408 WP_003026936.1 protein YgfX Toxin
CFU2785_RS04625 921601..922122 - 522 WP_003026933.1 flavodoxin FldB -
CFU2785_RS04630 922236..923132 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
CFU2785_RS04635 923156..923869 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CFU2785_RS04640 923875..925608 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T292850 WP_003026936.1 NZ_LS992183:921149-921556 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT292850 WP_003026938.1 NZ_LS992183:920902-921168 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References