Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 336286..336917 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag CFU2785_RS01635 Protein ID WP_003837806.1
Coordinates 336286..336561 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag CFU2785_RS01640 Protein ID WP_003837808.1
Coordinates 336558..336917 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS01625 332337..335084 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
CFU2785_RS01630 335084..336208 + 1125 WP_003837801.1 ABC transporter permease -
CFU2785_RS01635 336286..336561 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
CFU2785_RS01640 336558..336917 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CFU2785_RS01645 337028..337429 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
CFU2785_RS01650 337479..338057 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
CFU2785_RS01655 338120..339169 - 1050 WP_003023393.1 AI-2E family transporter -
CFU2785_RS01660 339303..340520 + 1218 WP_032950436.1 MFS transporter -
CFU2785_RS01665 340524..341081 - 558 WP_003837816.1 DcrB family lipoprotein -
CFU2785_RS01670 341154..341819 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T292847 WP_003837806.1 NZ_LS992183:336286-336561 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT292847 WP_003837808.1 NZ_LS992183:336558-336917 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References