292844

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 83653..84178 Replicon plasmid 3
Accession NZ_LS992182
Organism Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)


Gene name ccdB Uniprot ID V0SSI5
Locus tag ECTO124_RS27185 Protein ID WP_001159868.1
Coordinates 83873..84178 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag ECTO124_RS27180 Protein ID WP_000813634.1
Coordinates 83653..83871 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO124_RS27155 78932..80545 - 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -
ECTO124_RS27160 80576..80926 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
ECTO124_RS27165 80923..81348 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
ECTO124_RS27170 81410..82561 + 1152 WP_031325939.1 DUF3800 domain-containing protein -
ECTO124_RS27175 82595..83107 - 513 WP_000151784.1 hypothetical protein -
ECTO124_RS27180 83653..83871 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
ECTO124_RS27185 83873..84178 + 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB Toxin
ECTO124_RS27190 84179..84985 + 807 WP_000016982.1 site-specific integrase -
ECTO124_RS27195 85759..86514 + 756 WP_000852146.1 replication initiation protein RepE -
ECTO124_RS27200 87102..88268 + 1167 WP_000772446.1 plasmid-partitioning protein SopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / aac(6')-Ib-cr / blaOXA-1 / blaCTX-M-15 / aadA5 / qacE / sul1 / mph(A) - 1..133139 133139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11706.51 Da        Isoelectric Point: 6.4674

>T292844 WP_001159868.1 NZ_LS992182:83873-84178 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT292844 WP_000813634.1 NZ_LS992182:83653-83871 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4VUB
PDB 2VUB
PDB 7EPI
PDB 7EPG
PDB 3VUB
PDB 1X75
PDB 1VUB
PDB 7EPJ
PDB 3HPW
PDB 3G7Z

Antitoxin

Source ID Structure
AlphaFold DB A0A829CQY2

References