292840

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 141266..141801 Replicon plasmid 2
Accession NZ_LS992181
Organism Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)


Gene name relE Uniprot ID A0A0M1UJC2
Locus tag ECTO124_RS26585 Protein ID WP_001270422.1
Coordinates 141514..141801 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag ECTO124_RS26580 Protein ID WP_001132895.1
Coordinates 141266..141517 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO124_RS26540 136283..136594 - 312 WP_001309256.1 hypothetical protein -
ECTO124_RS27645 136658..137017 - 360 WP_001336695.1 DUF1281 domain-containing protein -
ECTO124_RS27650 137024..137167 - 144 WP_000270807.1 DUF1281 domain-containing protein -
ECTO124_RS26560 137334..138110 - 777 Protein_166 hypothetical protein -
ECTO124_RS26565 138344..139306 - 963 WP_000756328.1 ParB/RepB/Spo0J family partition protein -
ECTO124_RS26570 139303..140508 - 1206 WP_000817635.1 AAA family ATPase -
ECTO124_RS26580 141266..141517 + 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ECTO124_RS26585 141514..141801 + 288 WP_001270422.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECTO124_RS26590 141803..142214 + 412 Protein_171 DDE-type integrase/transposase/recombinase -
ECTO124_RS26600 142846..143836 + 991 Protein_172 RepB family plasmid replication initiator protein -
ECTO124_RS26605 144079..144819 - 741 WP_001066947.1 tyrosine-type recombinase/integrase -
ECTO124_RS26610 144940..145128 - 189 WP_001332784.1 hypothetical protein -
ECTO124_RS26615 145495..146665 + 1171 Protein_175 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - senB 1..149633 149633
- flank IS/Tn - - 137547..137687 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11262.30 Da        Isoelectric Point: 10.4703

>T292840 WP_001270422.1 NZ_LS992181:141514-141801 [Escherichia coli]
MRYQVKFREDALKEWQKMDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT292840 WP_001132895.1 NZ_LS992181:141266-141517 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M1UJC2

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References