292831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 7173..7708 Replicon plasmid 2
Accession NZ_LS992181
Organism Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)


Gene name relE Uniprot ID A0A0M1UJC2
Locus tag ECTO124_RS25680 Protein ID WP_001270422.1
Coordinates 7421..7708 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag ECTO124_RS25675 Protein ID WP_001132895.1
Coordinates 7173..7424 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO124_RS25635 2199..2508 - 310 Protein_4 hypothetical protein -
ECTO124_RS25640 2534..2739 - 206 Protein_5 DUF1281 domain-containing protein -
ECTO124_RS27635 2941..3082 - 142 Protein_6 DUF1281 domain-containing protein -
ECTO124_RS25650 3063..3119 + 57 WP_134087824.1 DUF4113 domain-containing protein -
ECTO124_RS25655 3248..4023 - 776 Protein_8 hypothetical protein -
ECTO124_RS25660 4255..5154 - 900 Protein_9 ParB/RepB/Spo0J family partition protein -
ECTO124_RS25665 5210..6353 - 1144 Protein_10 ParA family protein -
ECTO124_RS25675 7173..7424 + 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ECTO124_RS25680 7421..7708 + 288 WP_001270422.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECTO124_RS25685 7710..8121 + 412 Protein_13 DDE-type integrase/transposase/recombinase -
ECTO124_RS25695 8765..9742 + 978 WP_001309253.1 RepB family plasmid replication initiator protein -
ECTO124_RS25700 9985..10725 - 741 WP_001066947.1 tyrosine-type recombinase/integrase -
ECTO124_RS25705 10846..11034 - 189 WP_001332784.1 hypothetical protein -
ECTO124_RS25710 11401..12570 + 1170 WP_001072358.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - senB 1..149633 149633
- flank IS/Tn - - 3475..3600 125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11262.30 Da        Isoelectric Point: 10.4703

>T292831 WP_001270422.1 NZ_LS992181:7421-7708 [Escherichia coli]
MRYQVKFREDALKEWQKMDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT292831 WP_001132895.1 NZ_LS992181:7173-7424 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M1UJC2

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References