292826

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4376255..4377075 Replicon chromosome
Accession NZ_LS992180
Organism Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag ECTO124_RS21910 Protein ID WP_001054379.1
Coordinates 4376255..4376512 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag ECTO124_RS21915 Protein ID WP_000123957.1
Coordinates 4376524..4377075 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO124_RS21890 4371802..4372782 + 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECTO124_RS21895 4373365..4374471 - 1107 Protein_4199 helicase YjhR -
ECTO124_RS21900 4374534..4375681 + 1148 WP_085949154.1 IS3-like element ISEc52 family transposase -
ECTO124_RS21905 4375714..4375878 + 165 Protein_4201 GNAT family N-acetyltransferase -
ECTO124_RS21910 4376255..4376512 + 258 WP_001054379.1 YjhX family toxin Toxin
ECTO124_RS21915 4376524..4377075 + 552 WP_000123957.1 N-acetyltransferase Antitoxin
ECTO124_RS21920 4377127..4377873 + 747 WP_000354249.1 class I SAM-dependent methyltransferase -
ECTO124_RS21925 4378001..4378261 + 261 WP_000077645.1 hypothetical protein -
ECTO124_RS27745 4378299..4378415 + 117 Protein_4206 VOC family protein -
ECTO124_RS21930 4378660..4379781 + 1122 WP_000010833.1 M42 family metallopeptidase -
ECTO124_RS21935 4379778..4380056 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECTO124_RS21940 4380068..4381381 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE 4364876..4385296 20420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T292826 WP_001054379.1 NZ_LS992180:4376255-4376512 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT292826 WP_000123957.1 NZ_LS992180:4376524-4377075 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6I030

Antitoxin

Source ID Structure

References