Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4216832..4217352 Replicon chromosome
Accession NZ_LS992180
Organism Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag ECTO124_RS21140 Protein ID WP_001160964.1
Coordinates 4216832..4217116 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag ECTO124_RS21145 Protein ID WP_000125566.1
Coordinates 4217119..4217352 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO124_RS21115 4212477..4213763 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
ECTO124_RS21120 4213763..4214752 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
ECTO124_RS21125 4214749..4215570 + 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
ECTO124_RS21130 4215573..4215950 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
ECTO124_RS21135 4215957..4216805 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
ECTO124_RS21140 4216832..4217116 - 285 WP_001160964.1 CcdB family protein Toxin
ECTO124_RS21145 4217119..4217352 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
ECTO124_RS21150 4217438..4217917 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
ECTO124_RS21155 4218109..4219971 - 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
ECTO124_RS21160 4219964..4220494 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
ECTO124_RS21165 4220602..4221933 - 1332 WP_001183209.1 MFS transporter -
ECTO124_RS21170 4221992..4222279 - 288 WP_000203744.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T292824 WP_001160964.1 NZ_LS992180:c4217116-4216832 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT292824 WP_000125566.1 NZ_LS992180:c4217352-4217119 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References