Detailed information of TA system TA292823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3947791..3949480
• Replicon: chromosome
• Accession: NZ_LS992180
• Organism: Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: ECTO124_RS19850
• Protein ID: WP_000365807.1
• Coordinates: 3947791..3948711 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ECTO124_RS19855
• Protein ID: WP_001295795.1
• Coordinates: 3948698..3949480 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECTO124_RS19810	3943264..3943974	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
ECTO124_RS19815	3944281..3944610	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
ECTO124_RS19820	3944622..3944785	-	164	Protein_3795	tail fiber assembly protein	-
ECTO124_RS19825	3944859..3945473	-	615	WP_001019923.1	YagU family protein	-
ECTO124_RS19830	3945688..3945873	-	186	WP_000146240.1	hypothetical protein	-
ECTO124_RS27625	3945922..3946080	+	159	Protein_3798	integrase	-
ECTO124_RS19840	3946307..3946642	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
ECTO124_RS19845	3946850..3947626	+	777	WP_000171155.1	site-specific integrase	-
ECTO124_RS19850	3947791..3948711	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ECTO124_RS19855	3948698..3949480	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
ECTO124_RS19860	3949764..3952862	+	3099	WP_000673070.1	type I restriction endonuclease subunit R	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3907575..3956543	48968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T292823 WP_000365807.1 NZ_LS992180:c3948711-3947791 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT292823 WP_001295795.1 NZ_LS992180:c3949480-3948698 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0