Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2548569..2550157 | Replicon | chromosome |
Accession | NZ_LS992180 | ||
Organism | Escherichia coli isolate Escherichia coli str. TO124 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A061YM43 |
Locus tag | ECTO124_RS12665 | Protein ID | WP_001125411.1 |
Coordinates | 2548835..2550157 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A061YNW4 |
Locus tag | ECTO124_RS12660 | Protein ID | WP_001296076.1 |
Coordinates | 2548569..2548835 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ECTO124_RS12640 | 2543676..2545094 | + | 1419 | WP_000558459.1 | GGDEF domain-containing protein | - |
ECTO124_RS12645 | 2545321..2546772 | + | 1452 | WP_000854638.1 | tagaturonate reductase | - |
ECTO124_RS12650 | 2546969..2547883 | + | 915 | WP_001296077.1 | bestrophin family protein | - |
ECTO124_RS12655 | 2547887..2548261 | - | 375 | WP_123312538.1 | methyltransferase domain-containing protein | - |
ECTO124_RS12660 | 2548569..2548835 | + | 267 | WP_001296076.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
ECTO124_RS12665 | 2548835..2550157 | + | 1323 | WP_001125411.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
ECTO124_RS12680 | 2551068..2551631 | + | 564 | WP_001296074.1 | type 1 fimbrial major subunit FimA | - |
ECTO124_RS12685 | 2551993..2552703 | + | 711 | WP_001195176.1 | fimbria/pilus periplasmic chaperone | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49329.96 Da Isoelectric Point: 7.7906
>T292820 WP_001125411.1 NZ_LS992180:2548835-2550157 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061YM43 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061YNW4 |