Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2548569..2550157 Replicon chromosome
Accession NZ_LS992180
Organism Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)


Gene name hipA Uniprot ID A0A061YM43
Locus tag ECTO124_RS12665 Protein ID WP_001125411.1
Coordinates 2548835..2550157 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag ECTO124_RS12660 Protein ID WP_001296076.1
Coordinates 2548569..2548835 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO124_RS12640 2543676..2545094 + 1419 WP_000558459.1 GGDEF domain-containing protein -
ECTO124_RS12645 2545321..2546772 + 1452 WP_000854638.1 tagaturonate reductase -
ECTO124_RS12650 2546969..2547883 + 915 WP_001296077.1 bestrophin family protein -
ECTO124_RS12655 2547887..2548261 - 375 WP_123312538.1 methyltransferase domain-containing protein -
ECTO124_RS12660 2548569..2548835 + 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ECTO124_RS12665 2548835..2550157 + 1323 WP_001125411.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
ECTO124_RS12680 2551068..2551631 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
ECTO124_RS12685 2551993..2552703 + 711 WP_001195176.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49329.96 Da        Isoelectric Point: 7.7906

>T292820 WP_001125411.1 NZ_LS992180:2548835-2550157 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT292820 WP_001296076.1 NZ_LS992180:2548569-2548835 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YM43

Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References