292811

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 882606..883887 Replicon chromosome
Accession NZ_LS992180
Organism Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag ECTO124_RS04300 Protein ID WP_001114681.1
Coordinates 882606..883499 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag ECTO124_RS04305 Protein ID WP_000208383.1
Coordinates 883492..883887 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO124_RS04280 877756..878739 - 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -
ECTO124_RS04285 879365..880120 - 756 Protein_826 IS21-like element ISEc10 family helper ATPase IstB -
ECTO124_RS04290 880117..881616 - 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
ECTO124_RS04295 881965..882135 - 171 Protein_828 IS110 family transposase -
ECTO124_RS04300 882606..883499 - 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
ECTO124_RS04305 883492..883887 - 396 WP_000208383.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
ECTO124_RS04310 883956..884801 - 846 WP_023281696.1 DUF4942 domain-containing protein -
ECTO124_RS04315 884886..885083 - 198 WP_000839293.1 DUF957 domain-containing protein -
ECTO124_RS04320 885100..885588 - 489 WP_000761699.1 hypothetical protein -
ECTO124_RS04325 885585..885962 - 378 WP_000854689.1 TA system toxin CbtA family protein -
ECTO124_RS04330 886039..886419 - 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
ECTO124_RS04335 886469..887113 - 645 WP_000094916.1 hypothetical protein -
ECTO124_RS04340 887132..887353 - 222 WP_000692329.1 DUF987 domain-containing protein -
ECTO124_RS04345 887416..887892 - 477 WP_001186726.1 RadC family protein -
ECTO124_RS04350 887908..888393 - 486 WP_000849566.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T292811 WP_001114681.1 NZ_LS992180:c883499-882606 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT292811 WP_000208383.1 NZ_LS992180:c883887-883492 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References