292807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 45960..46795 Replicon chromosome
Accession NZ_LS992180
Organism Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag ECTO124_RS00240 Protein ID WP_001094448.1
Coordinates 45960..46337 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag ECTO124_RS00245 Protein ID WP_024175935.1
Coordinates 46427..46795 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO124_RS00210 41328..42146 + 819 WP_000779409.1 lipoprotein NlpA -
ECTO124_RS00215 42150..43073 - 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
ECTO124_RS00220 43251..43748 - 498 WP_000509815.1 hypothetical protein -
ECTO124_RS00225 44341..45186 - 846 WP_000065751.1 DUF4942 domain-containing protein -
ECTO124_RS00230 45242..45463 - 222 WP_001296561.1 DUF957 domain-containing protein -
ECTO124_RS00235 45475..45963 - 489 WP_000761714.1 hypothetical protein -
ECTO124_RS00240 45960..46337 - 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
ECTO124_RS00245 46427..46795 - 369 WP_024175935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECTO124_RS00250 46869..47090 - 222 WP_000692346.1 DUF987 domain-containing protein -
ECTO124_RS00255 47159..47635 - 477 WP_001186709.1 RadC family protein -
ECTO124_RS00260 47647..48132 - 486 WP_000214415.1 antirestriction protein -
ECTO124_RS00265 48224..49042 - 819 WP_001234753.1 DUF945 domain-containing protein -
ECTO124_RS00270 49133..49366 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T292807 WP_001094448.1 NZ_LS992180:c46337-45960 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT292807 WP_024175935.1 NZ_LS992180:c46795-46427 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7EC32

References