292804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4830031..4830697 Replicon chromosome
Accession NZ_LS992175
Organism Citrobacter freundii isolate Citrobacter freundii str. E2614

Toxin (Protein)


Gene name tad Uniprot ID A0A0D7LIM5
Locus tag CFE2614_RS24065 Protein ID WP_044702260.1
Coordinates 4830338..4830697 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0D7LIR0
Locus tag CFE2614_RS24060 Protein ID WP_003844682.1
Coordinates 4830031..4830348 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFE2614_RS24030 4825698..4826522 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CFE2614_RS24035 4826591..4827814 + 1224 WP_044702265.1 L-sorbose 1-phosphate reductase -
CFE2614_RS24040 4827816..4828628 + 813 WP_044702264.1 shikimate 5-dehydrogenase -
CFE2614_RS24045 4828680..4829036 - 357 WP_032948294.1 hypothetical protein -
CFE2614_RS24050 4829178..4829339 + 162 WP_003841416.1 phage protein -
CFE2614_RS24055 4829743..4830021 + 279 WP_044702262.1 putative addiction module antidote protein -
CFE2614_RS24060 4830031..4830348 - 318 WP_003844682.1 helix-turn-helix domain-containing protein Antitoxin
CFE2614_RS24065 4830338..4830697 - 360 WP_044702260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFE2614_RS24070 4830911..4831600 + 690 WP_003841421.1 dipeptidase PepE -
CFE2614_RS24075 4831666..4833297 - 1632 WP_032938230.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13437.49 Da        Isoelectric Point: 10.2555

>T292804 WP_044702260.1 NZ_LS992175:c4830697-4830338 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11466.35 Da        Isoelectric Point: 9.0005

>AT292804 WP_003844682.1 NZ_LS992175:c4830348-4830031 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LIM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LIR0

References