Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4582033..4582549 Replicon chromosome
Accession NZ_LS992175
Organism Citrobacter freundii isolate Citrobacter freundii str. E2614

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CFE2614_RS22855 Protein ID WP_044699148.1
Coordinates 4582033..4582317 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag CFE2614_RS22860 Protein ID WP_003839576.1
Coordinates 4582307..4582549 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFE2614_RS22840 4578358..4578942 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
CFE2614_RS22845 4579320..4581458 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
CFE2614_RS22850 4581565..4582029 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CFE2614_RS22855 4582033..4582317 - 285 WP_044699148.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFE2614_RS22860 4582307..4582549 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CFE2614_RS22865 4582627..4584540 - 1914 WP_003839574.1 BglG family transcription antiterminator -
CFE2614_RS22870 4584562..4585302 - 741 WP_044699149.1 KDGP aldolase family protein -
CFE2614_RS22875 4585299..4586417 - 1119 WP_044699152.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CFE2614_RS22880 4586401..4587534 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10865.69 Da        Isoelectric Point: 10.1988

>T292803 WP_044699148.1 NZ_LS992175:c4582317-4582033 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
RQHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT292803 WP_003839576.1 NZ_LS992175:c4582549-4582307 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References