292802

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 4100858..4101537 Replicon chromosome
Accession NZ_LS992175
Organism Citrobacter freundii isolate Citrobacter freundii str. E2614

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1B7JLK7
Locus tag CFE2614_RS20520 Protein ID WP_003031349.1
Coordinates 4101196..4101537 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A1B7JLJ2
Locus tag CFE2614_RS20515 Protein ID WP_003031347.1
Coordinates 4100858..4101175 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFE2614_RS20490 4096951..4098948 - 1998 WP_016245729.1 choline BCCT transporter BetT -
CFE2614_RS20495 4099452..4099643 + 192 Protein_3919 DUF905 family protein -
CFE2614_RS20500 4099657..4100118 + 462 WP_003031344.1 antirestriction protein -
CFE2614_RS20505 4100134..4100610 + 477 WP_003031345.1 RadC family protein -
CFE2614_RS20510 4100619..4100840 + 222 WP_003031346.1 DUF987 domain-containing protein -
CFE2614_RS20515 4100858..4101175 + 318 WP_003031347.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CFE2614_RS20520 4101196..4101537 + 342 WP_003031349.1 type IV toxin-antitoxin system toxin YkfI Toxin
CFE2614_RS20525 4102127..4102618 - 492 WP_121927018.1 tail fiber assembly protein -
CFE2614_RS20530 4103739..4104182 - 444 Protein_3926 phage tail protein -
CFE2614_RS20535 4104182..4104862 - 681 WP_121927014.1 DUF2612 domain-containing protein -
CFE2614_RS20540 4104859..4106058 - 1200 WP_121927013.1 baseplate J/gp47 family protein -
CFE2614_RS20545 4106059..4106412 - 354 WP_016239889.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4085894..4144353 58459


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12921.01 Da        Isoelectric Point: 9.6543

>T292802 WP_003031349.1 NZ_LS992175:4101196-4101537 [Citrobacter freundii]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12094.74 Da        Isoelectric Point: 7.0370

>AT292802 WP_003031347.1 NZ_LS992175:4100858-4101175 [Citrobacter freundii]
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIEYRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JLK7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JLJ2

References