Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 884443..884982 Replicon chromosome
Accession NC_020833
Organism Mannheimia haemolytica USDA-ARS-USMARC-183

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag D650_RS04485 Protein ID WP_006247804.1
Coordinates 884443..884712 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag D650_RS04490 Protein ID WP_006247803.1
Coordinates 884716..884982 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D650_RS04440 879577..879876 + 300 WP_006247810.1 XRE family transcriptional regulator -
D650_RS13790 879885..880043 - 159 WP_006247809.1 hypothetical protein -
D650_RS04445 880053..880739 - 687 WP_006247808.1 hypothetical protein -
D650_RS04450 880850..881461 - 612 WP_006253310.1 hypothetical protein -
D650_RS04455 881510..882136 - 627 WP_006247807.1 tail assembly protein -
D650_RS04465 882358..883077 - 720 WP_006247806.1 preprotein translocase subunit YajC -
D650_RS04470 883067..883357 - 291 Protein_836 C40 family peptidase -
D650_RS04475 883335..884045 - 711 WP_006253312.1 tape measure protein -
D650_RS04480 884105..884368 - 264 WP_006247805.1 hypothetical protein -
D650_RS04485 884443..884712 - 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
D650_RS04490 884716..884982 - 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D650_RS04495 885050..885280 - 231 WP_006247802.1 DUF4035 domain-containing protein -
D650_RS04500 885325..885726 - 402 WP_006247801.1 hypothetical protein -
D650_RS04505 885809..886450 - 642 WP_006247800.1 hypothetical protein -
D650_RS04510 886482..886877 - 396 WP_006247799.1 phage tail protein -
D650_RS04515 886902..887129 - 228 Protein_845 phage terminase large subunit family protein -
D650_RS04520 887279..887653 + 375 WP_006247798.1 hypothetical protein -
D650_RS04525 887661..887828 + 168 WP_006253314.1 DNA cytosine methyltransferase -
D650_RS04530 887909..888232 + 324 WP_006253316.1 helix-turn-helix domain-containing protein -
D650_RS04535 888136..888846 + 711 Protein_849 tyrosine-type recombinase/integrase -
D650_RS04540 888947..889582 + 636 Protein_850 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 873389..898889 25500
- flank IS/Tn - - 888947..889639 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T29280 WP_006247804.1 NC_020833:c884712-884443 [Mannheimia haemolytica USDA-ARS-USMARC-183]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T29280 NC_020833:c884712-884443 [Mannheimia haemolytica USDA-ARS-USMARC-183]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT29280 WP_006247803.1 NC_020833:c884982-884716 [Mannheimia haemolytica USDA-ARS-USMARC-183]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT29280 NC_020833:c884982-884716 [Mannheimia haemolytica USDA-ARS-USMARC-183]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References