Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 933403..934057 Replicon chromosome
Accession NZ_LS992175
Organism Citrobacter freundii isolate Citrobacter freundii str. E2614

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag CFE2614_RS04725 Protein ID WP_003026936.1
Coordinates 933650..934057 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag CFE2614_RS04720 Protein ID WP_003026938.1
Coordinates 933403..933669 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFE2614_RS04695 928604..930037 - 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -
CFE2614_RS04700 930158..930886 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
CFE2614_RS04705 930939..931250 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
CFE2614_RS04710 931413..932072 + 660 WP_003838267.1 hemolysin III family protein -
CFE2614_RS04715 932166..933146 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
CFE2614_RS04720 933403..933669 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
CFE2614_RS04725 933650..934057 + 408 WP_003026936.1 protein YgfX Toxin
CFE2614_RS04730 934102..934623 - 522 WP_003026933.1 flavodoxin FldB -
CFE2614_RS04735 934737..935633 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
CFE2614_RS04740 935657..936370 + 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CFE2614_RS04745 936376..938109 + 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T292796 WP_003026936.1 NZ_LS992175:933650-934057 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT292796 WP_003026938.1 NZ_LS992175:933403-933669 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References