Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 680..1202 Replicon plasmid 3
Accession NZ_LS992173
Organism Escherichia coli isolate Escherichia coli str. TO73

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag ECTO73_RS23985 Protein ID WP_000220560.1
Coordinates 680..961 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag ECTO73_RS23990 Protein ID WP_000121743.1
Coordinates 951..1202 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO73_RS23980 211..534 - 324 WP_001181903.1 hypothetical protein -
ECTO73_RS23985 680..961 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECTO73_RS23990 951..1202 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
ECTO73_RS24000 2264..3118 + 855 WP_001239324.1 replication initiation protein -
ECTO73_RS24005 3143..3589 + 447 WP_001074386.1 hypothetical protein -
ECTO73_RS24010 3657..4082 + 426 WP_015058974.1 TaxD -
ECTO73_RS24015 4079..5056 - 978 WP_001579336.1 hypothetical protein -
ECTO73_RS24020 5081..5362 - 282 WP_001185482.1 hypothetical protein -
ECTO73_RS24025 5462..6124 - 663 WP_000516402.1 peptidyl-arginine deiminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-52B - 1..16544 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T292792 WP_000220560.1 NZ_LS992173:c961-680 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT292792 WP_000121743.1 NZ_LS992173:c1202-951 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References