292779

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4056183..4057003 Replicon chromosome
Accession NZ_LS992171
Organism Escherichia coli isolate Escherichia coli str. TO73

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag ECTO73_RS19830 Protein ID WP_001054379.1
Coordinates 4056183..4056440 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag ECTO73_RS19835 Protein ID WP_000123957.1
Coordinates 4056452..4057003 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO73_RS19810 4051470..4052576 + 1107 WP_001295733.1 N-acetylneuraminate epimerase -
ECTO73_RS19815 4052640..4053620 + 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECTO73_RS19820 4054203..4055429 - 1227 Protein_3848 helicase YjhR -
ECTO73_RS19825 4055507..4055806 + 300 WP_001332034.1 GNAT family N-acetyltransferase -
ECTO73_RS19830 4056183..4056440 + 258 WP_001054379.1 YjhX family toxin Toxin
ECTO73_RS19835 4056452..4057003 + 552 WP_000123957.1 N-acetyltransferase Antitoxin
ECTO73_RS19840 4057055..4057801 + 747 WP_000354249.1 class I SAM-dependent methyltransferase -
ECTO73_RS19845 4057929..4058189 + 261 WP_000077645.1 hypothetical protein -
ECTO73_RS24295 4058227..4058343 + 117 Protein_3854 VOC family protein -
ECTO73_RS19850 4058588..4059709 + 1122 WP_000010833.1 M42 family metallopeptidase -
ECTO73_RS19855 4059706..4059984 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECTO73_RS19860 4059996..4061309 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T292779 WP_001054379.1 NZ_LS992171:4056183-4056440 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT292779 WP_000123957.1 NZ_LS992171:4056452-4057003 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6I030

Antitoxin

Source ID Structure

References