292778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4019242..4019818 Replicon chromosome
Accession NZ_LS992171
Organism Escherichia coli isolate Escherichia coli str. TO73

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag ECTO73_RS19645 Protein ID WP_001297643.1
Coordinates 4019531..4019818 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag ECTO73_RS19640 Protein ID WP_000063156.1
Coordinates 4019242..4019544 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO73_RS19625 4015838..4017988 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
ECTO73_RS19630 4018038..4018241 + 204 WP_000467859.1 YbdD/YjiX family protein -
ECTO73_RS19635 4018252..4019208 + 957 WP_001297640.1 GTPase -
ECTO73_RS19640 4019242..4019544 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
ECTO73_RS19645 4019531..4019818 - 288 WP_001297643.1 BrnT family toxin Toxin
ECTO73_RS19650 4020017..4020714 - 698 Protein_3814 IS1 family transposase -
ECTO73_RS19655 4020771..4020866 + 96 Protein_3815 dienelactone hydrolase family protein -
ECTO73_RS19660 4021012..4022244 + 1233 WP_063104094.1 multidrug efflux MFS transporter MdtM -
ECTO73_RS19665 4022285..4023565 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T292778 WP_001297643.1 NZ_LS992171:c4019818-4019531 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT292778 WP_000063156.1 NZ_LS992171:c4019544-4019242 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References