292774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2435284..2435922 Replicon chromosome
Accession NZ_LS992171
Organism Escherichia coli isolate Escherichia coli str. TO73

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag ECTO73_RS11975 Protein ID WP_001447010.1
Coordinates 2435746..2435922 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ECTO73_RS11970 Protein ID WP_001270286.1
Coordinates 2435284..2435700 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO73_RS11950 2430436..2431377 - 942 WP_001251304.1 ABC transporter permease -
ECTO73_RS11955 2431378..2432391 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
ECTO73_RS11960 2432409..2433554 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
ECTO73_RS11965 2433799..2435205 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
ECTO73_RS11970 2435284..2435700 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ECTO73_RS11975 2435746..2435922 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ECTO73_RS11980 2436144..2436374 + 231 WP_000494244.1 YncJ family protein -
ECTO73_RS11985 2436466..2438427 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ECTO73_RS11990 2438500..2439036 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
ECTO73_RS11995 2439089..2440303 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T292774 WP_001447010.1 NZ_LS992171:c2435922-2435746 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT292774 WP_001270286.1 NZ_LS992171:c2435700-2435284 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References