292772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2243613..2244139 Replicon chromosome
Accession NZ_LS992171
Organism Escherichia coli isolate Escherichia coli str. TO73

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ECTO73_RS10965 Protein ID WP_000323025.1
Coordinates 2243852..2244139 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ECTO73_RS10960 Protein ID WP_000534858.1
Coordinates 2243613..2243852 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO73_RS10925 2238972..2239319 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
ECTO73_RS10930 2239316..2239720 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
ECTO73_RS24255 2239942..2240229 + 288 Protein_2116 hypothetical protein -
ECTO73_RS10945 2240998..2242311 + 1314 WP_000589005.1 ISNCY family transposase -
ECTO73_RS10950 2242748..2243080 - 333 WP_001301033.1 protein FlxA -
ECTO73_RS10955 2243283..2243588 - 306 WP_001326990.1 hypothetical protein -
ECTO73_RS10960 2243613..2243852 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ECTO73_RS10965 2243852..2244139 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ECTO73_RS10970 2244211..2244366 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ECTO73_RS10975 2244583..2244834 + 252 WP_000980994.1 hypothetical protein -
ECTO73_RS10980 2244901..2245179 + 279 WP_012304870.1 hypothetical protein -
ECTO73_RS10985 2245181..2246230 + 1050 WP_001265199.1 DUF968 domain-containing protein -
ECTO73_RS10990 2246244..2246996 + 753 WP_001047135.1 antitermination protein -
ECTO73_RS10995 2247274..2247363 - 90 WP_120795389.1 hypothetical protein -
ECTO73_RS11000 2247418..2247630 - 213 WP_000087756.1 cold shock-like protein CspF -
ECTO73_RS11005 2247931..2248146 + 216 WP_000066484.1 cold shock-like protein CspB -
ECTO73_RS24390 2248510..2248680 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
ECTO73_RS11010 2248900..2249109 + 210 WP_032347816.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2228033..2290957 62924
- inside Prophage - - 2211149..2307154 96005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T292772 WP_000323025.1 NZ_LS992171:2243852-2244139 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT292772 WP_000534858.1 NZ_LS992171:2243613-2243852 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References