Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4269890..4270710 Replicon chromosome
Accession NZ_LS992168
Organism Escherichia coli isolate Escherichia coli str. TO60

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag ECTO60_RS21295 Protein ID WP_001054379.1
Coordinates 4269890..4270147 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag ECTO60_RS21300 Protein ID WP_000123957.1
Coordinates 4270159..4270710 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO60_RS21275 4265437..4266417 + 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECTO60_RS21280 4267000..4268106 - 1107 Protein_4094 helicase YjhR -
ECTO60_RS21285 4268169..4269316 + 1148 WP_085949154.1 IS3-like element ISEc52 family transposase -
ECTO60_RS21290 4269349..4269513 + 165 Protein_4096 GNAT family N-acetyltransferase -
ECTO60_RS21295 4269890..4270147 + 258 WP_001054379.1 YjhX family toxin Toxin
ECTO60_RS21300 4270159..4270710 + 552 WP_000123957.1 N-acetyltransferase Antitoxin
ECTO60_RS21305 4270762..4271508 + 747 WP_000354249.1 class I SAM-dependent methyltransferase -
ECTO60_RS21310 4271636..4271896 + 261 WP_000077645.1 hypothetical protein -
ECTO60_RS26725 4271934..4272050 + 117 Protein_4101 VOC family protein -
ECTO60_RS21315 4272295..4273416 + 1122 WP_000010833.1 M42 family metallopeptidase -
ECTO60_RS21320 4273413..4273691 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECTO60_RS21325 4273703..4275016 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE 4258511..4278931 20420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T292745 WP_001054379.1 NZ_LS992168:4269890-4270147 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT292745 WP_000123957.1 NZ_LS992168:4270159-4270710 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6I030

Antitoxin

Source ID Structure

References