Detailed information of TA system TA292742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3842862..3844551
• Replicon: chromosome
• Accession: NZ_LS992168
• Organism: Escherichia coli isolate Escherichia coli str. TO60

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: ECTO60_RS19240
• Protein ID: WP_000365807.1
• Coordinates: 3842862..3843782 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ECTO60_RS19245
• Protein ID: WP_001295795.1
• Coordinates: 3843769..3844551 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECTO60_RS19200	3838335..3839045	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
ECTO60_RS19205	3839352..3839681	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
ECTO60_RS19210	3839693..3839856	-	164	Protein_3692	tail fiber assembly protein	-
ECTO60_RS19215	3839930..3840544	-	615	WP_001019923.1	YagU family protein	-
ECTO60_RS19220	3840759..3840944	-	186	WP_000146240.1	hypothetical protein	-
ECTO60_RS26620	3840993..3841151	+	159	Protein_3695	integrase	-
ECTO60_RS19230	3841378..3841713	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
ECTO60_RS19235	3841921..3842697	+	777	WP_000171155.1	site-specific integrase	-
ECTO60_RS19240	3842862..3843782	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ECTO60_RS19245	3843769..3844551	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
ECTO60_RS19250	3844835..3847933	+	3099	WP_000673070.1	type I restriction endonuclease subunit R	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3802645..3851614	48969

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T292742 WP_000365807.1 NZ_LS992168:c3843782-3842862 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT292742 WP_001295795.1 NZ_LS992168:c3844551-3843769 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0