Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3659555..3660173 Replicon chromosome
Accession NZ_LS992168
Organism Escherichia coli isolate Escherichia coli str. TO60

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ECTO60_RS18370 Protein ID WP_001291435.1
Coordinates 3659955..3660173 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ECTO60_RS18365 Protein ID WP_000344800.1
Coordinates 3659555..3659929 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO60_RS18355 3654644..3655837 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ECTO60_RS18360 3655860..3659009 + 3150 WP_001132478.1 multidrug efflux RND transporter permease subunit -
ECTO60_RS18365 3659555..3659929 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ECTO60_RS18370 3659955..3660173 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
ECTO60_RS18375 3660347..3660898 + 552 WP_000102539.1 maltose O-acetyltransferase -
ECTO60_RS18380 3661014..3661484 + 471 WP_000136192.1 YlaC family protein -
ECTO60_RS18385 3661648..3663198 + 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ECTO60_RS18390 3663240..3663593 - 354 WP_000878135.1 DUF1428 family protein -
ECTO60_RS18400 3663972..3664283 + 312 WP_000409908.1 MGMT family protein -
ECTO60_RS18405 3664314..3664886 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T292741 WP_001291435.1 NZ_LS992168:3659955-3660173 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT292741 WP_000344800.1 NZ_LS992168:3659555-3659929 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References