Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 288248..289048 Replicon chromosome
Accession NZ_LS992168
Organism Escherichia coli isolate Escherichia coli str. TO60

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag ECTO60_RS01355 Protein ID WP_000342452.1
Coordinates 288521..289048 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag ECTO60_RS01350 Protein ID WP_001277107.1
Coordinates 288248..288514 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO60_RS01330 283907..284575 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
ECTO60_RS01335 284568..285626 + 1059 WP_001042013.1 permease-like cell division protein FtsX -
ECTO60_RS01340 285871..286725 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
ECTO60_RS01345 286996..288099 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
ECTO60_RS01350 288248..288514 + 267 WP_001277107.1 DUF1778 domain-containing protein Antitoxin
ECTO60_RS01355 288521..289048 + 528 WP_000342452.1 GNAT family N-acetyltransferase Toxin
ECTO60_RS01360 289045..289428 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
ECTO60_RS01365 289851..290960 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
ECTO60_RS01370 291008..291934 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
ECTO60_RS01375 291931..293208 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
ECTO60_RS01380 293205..293972 + 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T292728 WP_000342452.1 NZ_LS992168:288521-289048 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT292728 WP_001277107.1 NZ_LS992168:288248-288514 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References