292726

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 98284..98831 Replicon plasmid 2
Accession NZ_LS992167
Organism Escherichia coli isolate Escherichia coli str. TO6

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag ECTO6_RS24390 Protein ID WP_000969990.1
Coordinates 98284..98565 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag ECTO6_RS24395 Protein ID WP_000079941.1
Coordinates 98562..98831 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO6_RS25060 95963..96124 + 162 WP_000251882.1 hypothetical protein -
ECTO6_RS24370 96142..96489 - 348 WP_000142450.1 hypothetical protein -
ECTO6_RS24380 96791..97273 - 483 WP_001311056.1 hypothetical protein -
ECTO6_RS24385 97390..98238 - 849 WP_106912714.1 3'-5' exonuclease -
ECTO6_RS24390 98284..98565 - 282 WP_000969990.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECTO6_RS24395 98562..98831 - 270 WP_000079941.1 hypothetical protein Antitoxin
ECTO6_RS24415 99636..101387 - 1752 Protein_109 Tn3-like element TnAs1 family transposase -
ECTO6_RS24420 101376..101783 + 408 WP_001214976.1 cysteine hydrolase -
ECTO6_RS24425 101921..102805 + 885 WP_000058717.1 EamA family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / tet(A) / mph(B) / sul1 / qacE / ant(3'')-Ia / dfrA1 / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B / catA1 iroN / iroE / iroD / iroC / iroB 1..174857 174857
- flank IS/Tn tet(A) - 99636..104036 4400


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10930.61 Da        Isoelectric Point: 8.4615

>T292726 WP_000969990.1 NZ_LS992167:c98565-98284 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTVQKWP

Download         Length: 282 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT292726 WP_000079941.1 NZ_LS992167:c98831-98562 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References