Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4200114..4200946 Replicon chromosome
Accession NZ_LS992166
Organism Escherichia coli isolate Escherichia coli str. TO6

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag ECTO6_RS20615 Protein ID WP_000854765.1
Coordinates 4200114..4200488 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag ECTO6_RS20620 Protein ID WP_001529626.1
Coordinates 4200578..4200946 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO6_RS20560 4195156..4196136 + 981 WP_001529628.1 transposase -
ECTO6_RS20565 4196144..4196794 - 651 WP_001037966.1 HNH endonuclease -
ECTO6_RS20595 4198032..4199260 + 1229 Protein_3998 IS3-like element IS2 family transposase -
ECTO6_RS20605 4199433..4199609 - 177 WP_000839288.1 DUF957 domain-containing protein -
ECTO6_RS20610 4199626..4200117 - 492 WP_000976842.1 hypothetical protein -
ECTO6_RS20615 4200114..4200488 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
ECTO6_RS20620 4200578..4200946 - 369 WP_001529626.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECTO6_RS20625 4201109..4201330 - 222 WP_000692345.1 DUF987 domain-containing protein -
ECTO6_RS20630 4201399..4201875 - 477 WP_001354275.1 RadC family protein -
ECTO6_RS20635 4201891..4202364 - 474 WP_001387789.1 antirestriction protein -
ECTO6_RS20645 4202706..4203524 - 819 WP_134091970.1 DUF945 domain-containing protein -
ECTO6_RS20655 4203679..4203837 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE 4190121..4202364 12243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T292719 WP_000854765.1 NZ_LS992166:c4200488-4200114 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13664.46 Da        Isoelectric Point: 6.3171

>AT292719 WP_001529626.1 NZ_LS992166:c4200946-4200578 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWELPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure

References