Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2381798..2382324 Replicon chromosome
Accession NZ_LS992166
Organism Escherichia coli isolate Escherichia coli str. TO6

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ECTO6_RS11755 Protein ID WP_000323025.1
Coordinates 2382037..2382324 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ECTO6_RS11750 Protein ID WP_000534858.1
Coordinates 2381798..2382037 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO6_RS11715 2376816..2377772 + 957 Protein_2264 Zn-dependent oxidoreductase -
ECTO6_RS11720 2377788..2378485 - 698 Protein_2265 IS1 family transposase -
ECTO6_RS11735 2379183..2380496 + 1314 WP_134091784.1 ISNCY family transposase -
ECTO6_RS11740 2380933..2381265 - 333 WP_134091787.1 FlxA-like family protein -
ECTO6_RS11745 2381468..2381773 - 306 WP_001326990.1 hypothetical protein -
ECTO6_RS11750 2381798..2382037 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ECTO6_RS11755 2382037..2382324 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ECTO6_RS11760 2382396..2382551 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ECTO6_RS11765 2382768..2383019 + 252 WP_000980994.1 hypothetical protein -
ECTO6_RS11770 2383086..2383364 + 279 WP_012304870.1 hypothetical protein -
ECTO6_RS11775 2383366..2384415 + 1050 WP_001265198.1 DUF968 domain-containing protein -
ECTO6_RS11780 2384429..2385181 + 753 WP_001047135.1 antitermination protein -
ECTO6_RS11785 2385459..2385548 - 90 WP_120795389.1 hypothetical protein -
ECTO6_RS11790 2385603..2385815 - 213 WP_000087756.1 cold shock-like protein CspF -
ECTO6_RS11795 2386116..2386331 + 216 WP_000066484.1 cold shock-like protein CspB -
ECTO6_RS25205 2386695..2386865 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
ECTO6_RS11800 2387085..2387300 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2377788..2418682 40894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T292713 WP_000323025.1 NZ_LS992166:2382037-2382324 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT292713 WP_000534858.1 NZ_LS992166:2381798-2382037 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References