Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2507867..2508517 Replicon chromosome
Accession NZ_LS991421
Organism Lacticaseibacillus zeae isolate CECT 9104

Toxin (Protein)


Gene name pemK Uniprot ID K8Q4Y0
Locus tag DYY97_RS12195 Protein ID WP_005686631.1
Coordinates 2507867..2508250 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0R1EMB2
Locus tag DYY97_RS12200 Protein ID WP_010491246.1
Coordinates 2508269..2508517 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYY97_RS12175 2503212..2504219 + 1008 WP_003662706.1 L-lactate dehydrogenase -
DYY97_RS12180 2504526..2505896 + 1371 WP_070650653.1 L,D-transpeptidase/peptidoglycan binding protein -
DYY97_RS12185 2506111..2506776 + 666 WP_010491258.1 CBS domain-containing protein -
DYY97_RS12190 2507099..2507797 + 699 WP_070650654.1 L,D-transpeptidase -
DYY97_RS12195 2507867..2508250 - 384 WP_005686631.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DYY97_RS12200 2508269..2508517 - 249 WP_010491246.1 antitoxin Antitoxin
DYY97_RS12205 2508616..2509755 - 1140 WP_070650655.1 alanine racemase -
DYY97_RS12210 2509742..2510116 - 375 WP_039639939.1 holo-ACP synthase -
DYY97_RS12215 2510354..2511862 - 1509 WP_047107145.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13757.03 Da        Isoelectric Point: 10.9764

>T292701 WP_005686631.1 NZ_LS991421:c2508250-2507867 [Lacticaseibacillus zeae]
MDVTVKRGDVFFADLSPVVGSEQGGNRPVLIIQNNVGNHYSPTVIVAAITSKIQKPKMPTHVGLRAKQDGVERNSVILLE
QIRTIDKQRLQARVTALSSAKMAAVDRALAISVGLVSLPKPKTYNKN

Download         Length: 384 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8971.07 Da        Isoelectric Point: 4.6061

>AT292701 WP_010491246.1 NZ_LS991421:c2508517-2508269 [Lacticaseibacillus zeae]
MKKQTSVTVTFDAAIKARLDAYCELNDTDTQDVITTAVAKFLQSQAPDINQLISGYVAMGQINTEISHAFSACESEAYAH
IR

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8Q4Y0

Antitoxin

Source ID Structure
AlphaFold DB A0A0R1EMB2

References