292697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1565657..1566269 Replicon chromosome
Accession NZ_LS483522
Organism Streptococcus pyogenes strain NCTC8224

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQN68_RS08130 Protein ID WP_002994716.1
Coordinates 1565934..1566269 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQN68_RS08125 Protein ID WP_002988079.1
Coordinates 1565657..1565944 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN68_RS08100 1560848..1561831 - 984 WP_111702287.1 tagatose-bisphosphate aldolase -
DQN68_RS08105 1561835..1562764 - 930 WP_020837785.1 tagatose-6-phosphate kinase -
DQN68_RS08110 1562810..1563325 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
DQN68_RS08115 1563360..1563788 - 429 WP_002991702.1 galactose-6-phosphate isomerase subunit LacA -
DQN68_RS08120 1564234..1565007 + 774 WP_023605292.1 DeoR/GlpR family DNA-binding transcription regulator -
DQN68_RS08125 1565657..1565944 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQN68_RS08130 1565934..1566269 + 336 WP_002994716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN68_RS09440 1566421..1566891 + 471 WP_021733374.1 site-specific integrase -
DQN68_RS09445 1566854..1567402 + 549 WP_136115776.1 site-specific integrase -
DQN68_RS08140 1567522..1567914 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQN68_RS08145 1567935..1568381 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQN68_RS08150 1568599..1568805 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQN68_RS08155 1568802..1569500 - 699 WP_172453869.1 hypothetical protein -
DQN68_RS08160 1569636..1570496 - 861 WP_002982687.1 DegV family protein -
DQN68_RS08165 1570593..1571111 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13154.89 Da        Isoelectric Point: 5.6157

>T292697 WP_002994716.1 NZ_LS483522:1565934-1566269 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292697 WP_002988079.1 NZ_LS483522:1565657-1565944 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References