Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1549046..1549658 Replicon chromosome
Accession NZ_LS483521
Organism Streptococcus pyogenes strain NCTC8316

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQL26_RS07735 Protein ID WP_014635711.1
Coordinates 1549323..1549658 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQL26_RS07730 Protein ID WP_002988079.1
Coordinates 1549046..1549333 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL26_RS07705 1544236..1545219 - 984 WP_111693403.1 tagatose-bisphosphate aldolase -
DQL26_RS07710 1545223..1546152 - 930 WP_002988085.1 tagatose-6-phosphate kinase -
DQL26_RS07715 1546198..1546713 - 516 WP_023612880.1 galactose-6-phosphate isomerase subunit LacB -
DQL26_RS07720 1546748..1547176 - 429 WP_111693404.1 galactose-6-phosphate isomerase subunit LacA -
DQL26_RS07725 1547623..1548396 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQL26_RS07730 1549046..1549333 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQL26_RS07735 1549323..1549658 + 336 WP_014635711.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL26_RS08960 1549809..1550279 + 471 Protein_1418 tyrosine-type recombinase/integrase family protein -
DQL26_RS07750 1550393..1550791 + 399 WP_181879099.1 tyrosine-type recombinase/integrase -
DQL26_RS07755 1550911..1551303 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQL26_RS07760 1551324..1551770 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQL26_RS07765 1551988..1552194 - 207 WP_111693406.1 helix-turn-helix transcriptional regulator -
DQL26_RS07770 1552191..1552889 - 699 WP_161230228.1 hypothetical protein -
DQL26_RS07775 1553025..1553885 - 861 WP_011529009.1 DegV family protein -
DQL26_RS07780 1553982..1554500 - 519 WP_111693408.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13173.94 Da        Isoelectric Point: 5.6809

>T292696 WP_014635711.1 NZ_LS483521:1549323-1549658 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292696 WP_002988079.1 NZ_LS483521:1549046-1549333 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References