Detailed information of TA system TA292695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 830446..831689
• Replicon: chromosome
• Accession: NZ_LS483521
• Organism: Streptococcus pyogenes strain NCTC8316

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: DQL26_RS04240
• Protein ID: WP_111693193.1
• Coordinates: 830922..831689 (+)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: DQL26_RS04235
• Protein ID: WP_111693192.1
• Coordinates: 830446..830922 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL26_RS04205	827708..827875	+	168	Protein_749	calcium-binding protein	-
DQL26_RS04210	827882..828079	+	198	Protein_750	hypothetical protein	-
DQL26_RS04215	828148..829253	+	1106	WP_111693067.1	IS3 family transposase	-
DQL26_RS04220	829424..829645	+	222	WP_111693189.1	hypothetical protein	-
DQL26_RS04225	829649..830044	+	396	WP_111693190.1	chemotaxis protein	-
DQL26_RS04230	830089..830376	+	288	WP_111693191.1	hypothetical protein	-
DQL26_RS04235	830446..830922	+	477	WP_111693192.1	helix-turn-helix domain-containing protein	Antitoxin
DQL26_RS04240	830922..831689	+	768	WP_111693193.1	zeta toxin family protein	Toxin
DQL26_RS04245	831705..832493	+	789	WP_029174746.1	hypothetical protein	-
DQL26_RS04250	832494..833636	+	1143	WP_111693194.1	AAA family ATPase	-
DQL26_RS04260	833963..834322	+	360	WP_111693195.1	hypothetical protein	-
DQL26_RS04265	834332..834697	+	366	WP_111693196.1	MobC family plasmid mobilization relaxosome protein	-
DQL26_RS04270	834684..835076	+	393	Protein_761	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	790978..885926	94948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 29238.18 Da
• Isoelectric Point: 6.3613

>T292695 WP_111693193.1 NZ_LS483521:830922-831689 [Streptococcus pyogenes]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVTPKAILLGRQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRPLHPNYLDLQE
KYGKDSVDYTKGFAEKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKGHHDGIVERLVDNLRELETNKLFDQIQIYQRDRTCVYDSETDEGPAADVLQDCLFGKWSKVEEEML
RDIEEKIANLKVSNE

Nucleotide

• Length: 768 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18162.57 Da
• Isoelectric Point: 4.6103

>AT292695 WP_111693192.1 NZ_LS483521:830446-830922 [Streptococcus pyogenes]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQKIAFDDETNPWILMSDDLSDLINTKIYLVQSFDEVERYNGYLDGIERILNLAHHQVVA

Nucleotide

• Length: 477 bp