Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 830446..831689 Replicon chromosome
Accession NZ_LS483521
Organism Streptococcus pyogenes strain NCTC8316

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag DQL26_RS04240 Protein ID WP_111693193.1
Coordinates 830922..831689 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag DQL26_RS04235 Protein ID WP_111693192.1
Coordinates 830446..830922 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL26_RS04205 827708..827875 + 168 Protein_749 calcium-binding protein -
DQL26_RS04210 827882..828079 + 198 Protein_750 hypothetical protein -
DQL26_RS04215 828148..829253 + 1106 WP_111693067.1 IS3 family transposase -
DQL26_RS04220 829424..829645 + 222 WP_111693189.1 hypothetical protein -
DQL26_RS04225 829649..830044 + 396 WP_111693190.1 chemotaxis protein -
DQL26_RS04230 830089..830376 + 288 WP_111693191.1 hypothetical protein -
DQL26_RS04235 830446..830922 + 477 WP_111693192.1 helix-turn-helix domain-containing protein Antitoxin
DQL26_RS04240 830922..831689 + 768 WP_111693193.1 zeta toxin family protein Toxin
DQL26_RS04245 831705..832493 + 789 WP_029174746.1 hypothetical protein -
DQL26_RS04250 832494..833636 + 1143 WP_111693194.1 AAA family ATPase -
DQL26_RS04260 833963..834322 + 360 WP_111693195.1 hypothetical protein -
DQL26_RS04265 834332..834697 + 366 WP_111693196.1 MobC family plasmid mobilization relaxosome protein -
DQL26_RS04270 834684..835076 + 393 Protein_761 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 790978..885926 94948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29238.18 Da        Isoelectric Point: 6.3613

>T292695 WP_111693193.1 NZ_LS483521:830922-831689 [Streptococcus pyogenes]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVTPKAILLGRQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRPLHPNYLDLQE
KYGKDSVDYTKGFAEKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKGHHDGIVERLVDNLRELETNKLFDQIQIYQRDRTCVYDSETDEGPAADVLQDCLFGKWSKVEEEML
RDIEEKIANLKVSNE

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18162.57 Da        Isoelectric Point: 4.6103

>AT292695 WP_111693192.1 NZ_LS483521:830446-830922 [Streptococcus pyogenes]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQKIAFDDETNPWILMSDDLSDLINTKIYLVQSFDEVERYNGYLDGIERILNLAHHQVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References