Detailed information of TA system TA292690

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1049876..1051309
• Replicon: chromosome
• Accession: NZ_LS483517
• Organism: Mycoplasma mycoides subsp. capri strain GM12 isolate synthetic

Toxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: EXZ39_RS04505
• Protein ID: WP_080511208.1
• Coordinates: 1049876..1050610 (-)
• Length: 245 a.a.

Antitoxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A7Z7PN10
• Locus tag: EXZ39_RS04510
• Protein ID: WP_020863064.1
• Coordinates: 1050710..1051309 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXZ39_RS04490	1046172..1047749	-	1578	WP_020863062.1	dicarboxylate/amino acid:cation symporter	-
EXZ39_RS04495	1047769..1049112	-	1344	WP_023905986.1	CoA-disulfide reductase	-
EXZ39_RS04500	1049330..1049830	+	501	WP_020863063.1	isochorismatase family protein	-
EXZ39_RS04505	1049876..1050610	-	735	WP_080511208.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EXZ39_RS04510	1050710..1051309	-	600	WP_020863064.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
EXZ39_RS04515	1051577..1051696	+	120	Protein_831	isochorismatase family protein	-
EXZ39_RS04520	1051886..1053220	+	1335	WP_020863065.1	DUF285 domain-containing protein	-
EXZ39_RS04750	1053470..1054693	+	1224	WP_020863066.1	phosphatase PAP2 family protein	-
EXZ39_RS04535	1054824..1056029	+	1206	WP_020863067.1	phosphatase PAP2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (4-210)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (5-53)

Sequences

Toxin

Protein

• Length: 245 a.a.
• Molecular weight: 28915.65 Da
• Isoelectric Point: 9.5052

>T292690 WP_080511208.1 NZ_LS483517:c1050610-1049876 [Mycoplasma mycoides subsp. capri]
MKKISKNKDKINIIFKGGFLLSNIIGIKERTTKDIDYLLNNIVFSPDRIKELFEDILDYKKGDKIHFQIQKINEIKKKEK
YTGFRITVECKLDEIVEIIKIDVATGDIITSCQVRYNIENIFHNNSFYVYGYNLETMLAEKIHAIKELSLFNTRTKDFYD
IYLIYNLKRDDIDYMTLKNACINTFKQRNSIFDKDDLLELLNKIKNSQSTHNLTKQKNIYFYNKNIDFKFIIQSIIELIK
NIK

Nucleotide

• Length: 735 bp

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 23847.67 Da
• Isoelectric Point: 8.3457

>AT292690 WP_020863064.1 NZ_LS483517:c1051309-1050710 [Mycoplasma mycoides subsp. capri]
MNYVEKIKEKAIQNNGLITRKEIISLKIPPIYITRMVRKKELEKIDIGIYALTSLDNYPYDPEFNFCSRYQVPVFSYVYA
LNLFDFTDVIPLNFEVTVYKGYNAHNLKPNTIVHYVNKEIFNLGITEIRNAFGNWVRTYDIERTICDLIKNRKNINVELF
VKTMNNYVNYEKKDWNKLYEYAEKMHIEKELVEIFQLII

Nucleotide

• Length: 600 bp

Structures

Antitoxin

• AlphaFold DB: A0A7Z7PN10