Detailed information of TA system TA292680

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 209998..211433
• Replicon: chromosome
• Accession: NZ_LS483508
• Organism: Mycoplasma mycoides subsp. capri strain GM12 isolate synthetic

Toxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: EXZ34_RS00860
• Protein ID: WP_020862545.1
• Coordinates: 209998..210750 (-)
• Length: 251 a.a.

Antitoxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A7Z7LCJ7
• Locus tag: EXZ34_RS00865
• Protein ID: WP_020862546.1
• Coordinates: 210837..211433 (-)
• Length: 199 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXZ34_RS00830 (MMC68H_00163)	205099..205764	-	666	WP_020862542.1	tRNA (guanosine(46)-N7)-methyltransferase TrmB	-
EXZ34_RS00835 (MMC68H_00164)	205766..207169	-	1404	WP_129909975.1	magnesium transporter	-
EXZ34_RS04655 (MMC68H_00166)	207849..209978	+	2130	WP_172597399.1	transglutaminase domain-containing protein	-
EXZ34_RS00860 (MMC68H_00167)	209998..210750	-	753	WP_020862545.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EXZ34_RS00865 (MMC68H_00168)	210837..211433	-	597	WP_020862546.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
EXZ34_RS00870 (MMC68H_00169)	211644..212612	-	969	WP_230453486.1	BspA family leucine-rich repeat surface protein	-
EXZ34_RS04825 (MMC68H_00170)	212584..212850	-	267	WP_232017462.1	lipoprotein	-
EXZ34_RS00875 (MMC68H_00171)	212964..215654	-	2691	WP_020862547.1	alanine--tRNA ligase	-
EXZ34_RS00880 (MMC68H_00172)	215728..216222	-	495	WP_017698022.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (4-234)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-53)

Sequences

Toxin

Protein

• Length: 251 a.a.
• Molecular weight: 29440.65 Da
• Isoelectric Point: 8.4012

>T292680 WP_020862545.1 NZ_LS483508:c210750-209998 [Mycoplasma mycoides subsp. capri]
MISILEKIVKSKNKQNFIIKGGFLLSNMMSLNERTTQDIDCLIKGINFVKENILKIISDVLRYDFTDFIEYEIKEITEIK
KRDKYNGFRVKILCKLEKLEEIVKIDLAIGDVITPSEIKYNFKNIFSNSSFEIQAYNLETILAEKIFIINNLNIQSTRIK
DLYDIFLIYSLKEFEIDYNILKCACLNTFKKRNTVFNIDLILNLLNEINQLDIFKLLNNYKQKYFYAQKIEFEILVESVI
KLLEKLKSS

Nucleotide

• Length: 753 bp

>T292680 NZ_LS483508:c210750-209998 [Mycoplasma mycoides subsp. capri]
ATGATATCCATATTAGAAAAAATTGTTAAAAGTAAAAATAAGCAAAACTTTATAATTAAAGGCGGATTCTTACTTTCTAA
TATGATGAGTTTAAACGAAAGAACCACTCAAGATATAGATTGCCTAATAAAGGGTATCAATTTTGTTAAAGAGAATATTC
TAAAAATTATTTCTGATGTACTAAGATATGATTTTACTGACTTTATAGAATATGAAATAAAAGAAATAACAGAAATAAAA
AAGAGAGACAAATATAATGGATTTAGAGTCAAAATATTATGTAAATTAGAAAAGTTAGAAGAAATAGTAAAAATAGATTT
AGCAATTGGTGATGTTATAACACCATCTGAGATTAAATACAATTTTAAAAATATCTTTTCAAATAGTAGCTTTGAAATAC
AAGCATATAATTTAGAAACGATATTAGCTGAAAAAATATTTATAATTAATAATTTAAATATACAATCAACTAGAATAAAA
GATCTTTATGATATTTTTTTAATATATAGTTTGAAAGAGTTTGAGATTGATTATAATATTCTAAAATGTGCTTGTTTAAA
TACTTTTAAAAAAAGAAATACTGTTTTTAATATAGATTTAATACTTAATTTATTAAATGAAATTAACCAATTAGATATTT
TTAAATTACTTTGAAATAATTACAAGCAAAAATACTTTTACGCTCAAAAAATAGAATTTGAAATACTGGTGGAATCTGTA
ATTAAGCTTTTAGAAAAGTTAAAAAGCTCTTAG

Antitoxin

Protein

• Length: 199 a.a.
• Molecular weight: 23622.23 Da
• Isoelectric Point: 9.3421

>AT292680 WP_020862546.1 NZ_LS483508:c211433-210837 [Mycoplasma mycoides subsp. capri]
MNYKEQLIKEAKKRDGLITRKEIINLKIPSIYITRMIRSNELEKVDIGIYALTSENWHYDPDYNFSIRHKTPIFSYTYAL
TFFDFTDVIPMFRDVTVYHGYNAHNLDPQTRVHYVSKDIYELGVVEVKTNCGNKVRAYNIERTICDFIKHRDKIEAELFA
KTMYKYSEYEKRDKKLHEYAKKMNIGKKVYEVFQVLV

Nucleotide

• Length: 597 bp

>AT292680 NZ_LS483508:c211433-210837 [Mycoplasma mycoides subsp. capri]
ATGAATTATAAAGAACAACTGATAAAAGAAGCCAAAAAAAGAGACGGTCTTATTACAAGAAAAGAAATTATAAATTTAAA
AATTCCATCAATTTATATTACAAGAATGATTAGAAGTAATGAATTAGAAAAAGTCGATATTGGTATTTATGCTCTAACTT
CTGAAAATTGGCACTATGATCCTGATTATAATTTTAGTATCAGACATAAAACACCTATTTTTTCTTATACTTATGCACTT
ACATTTTTTGATTTTACAGATGTTATTCCAATGTTTCGTGATGTAACTGTTTATCATGGATATAATGCTCATAATTTAGA
TCCACAAACTAGAGTACACTATGTTTCAAAAGATATATATGAACTTGGAGTTGTAGAAGTAAAAACAAATTGTGGTAATA
AAGTTAGAGCTTATAATATTGAAAGAACAATTTGTGACTTTATTAAACATAGAGATAAAATCGAAGCTGAACTATTTGCA
AAAACTATGTATAAATATTCTGAATATGAAAAAAGAGATTGAAAAAAACTTCATGAATATGCTAAAAAAATGAACATTGG
TAAGAAAGTTTATGAAGTTTTTCAAGTATTAGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z7LCJ7