Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1052626..1054059 Replicon chromosome
Accession NZ_LS483504
Organism Mycoplasma mycoides subsp. capri strain GM12 isolate synthetic

Toxin (Protein)


Gene name abiEii Uniprot ID -
Locus tag EXZ22_RS04520 Protein ID WP_080511208.1
Coordinates 1052626..1053360 (-) Length 245 a.a.

Antitoxin (Protein)


Gene name abiEi Uniprot ID A0A7Z7PN10
Locus tag EXZ22_RS04525 Protein ID WP_020863064.1
Coordinates 1053460..1054059 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXZ22_RS04505 1048922..1050499 - 1578 WP_129878795.1 dicarboxylate/amino acid:cation symporter -
EXZ22_RS04510 1050519..1051862 - 1344 WP_023905986.1 CoA-disulfide reductase -
EXZ22_RS04515 1052080..1052580 + 501 WP_129878797.1 isochorismatase family protein -
EXZ22_RS04520 1052626..1053360 - 735 WP_080511208.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
EXZ22_RS04525 1053460..1054059 - 600 WP_020863064.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
EXZ22_RS04530 1054327..1054446 + 120 Protein_835 isochorismatase family protein -
EXZ22_RS04535 1054636..1055970 + 1335 WP_129878799.1 DUF285 domain-containing protein -
EXZ22_RS04770 1056220..1057443 + 1224 WP_172597193.1 phosphatase PAP2 family protein -
EXZ22_RS04550 1057574..1058779 + 1206 WP_129878803.1 phosphatase PAP2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(4-210)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(5-53)


Sequences

Toxin        


Download         Length: 245 a.a.        Molecular weight: 28915.65 Da        Isoelectric Point: 9.5052

>T292676 WP_080511208.1 NZ_LS483504:c1053360-1052626 [Mycoplasma mycoides subsp. capri]
MKKISKNKDKINIIFKGGFLLSNIIGIKERTTKDIDYLLNNIVFSPDRIKELFEDILDYKKGDKIHFQIQKINEIKKKEK
YTGFRITVECKLDEIVEIIKIDVATGDIITSCQVRYNIENIFHNNSFYVYGYNLETMLAEKIHAIKELSLFNTRTKDFYD
IYLIYNLKRDDIDYMTLKNACINTFKQRNSIFDKDDLLELLNKIKNSQSTHNLTKQKNIYFYNKNIDFKFIIQSIIELIK
NIK

Download         Length: 735 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 23847.67 Da        Isoelectric Point: 8.3457

>AT292676 WP_020863064.1 NZ_LS483504:c1054059-1053460 [Mycoplasma mycoides subsp. capri]
MNYVEKIKEKAIQNNGLITRKEIISLKIPPIYITRMVRKKELEKIDIGIYALTSLDNYPYDPEFNFCSRYQVPVFSYVYA
LNLFDFTDVIPLNFEVTVYKGYNAHNLKPNTIVHYVNKEIFNLGITEIRNAFGNWVRTYDIERTICDLIKNRKNINVELF
VKTMNNYVNYEKKDWNKLYEYAEKMHIEKELVEIFQLII

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7PN10

References