292674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1054674..1056107 Replicon chromosome
Accession NZ_LS483501
Organism Mycoplasma mycoides subsp. capri strain GM12 isolate synthetic

Toxin (Protein)


Gene name abiEii Uniprot ID -
Locus tag EXZ29_RS04525 Protein ID WP_080511208.1
Coordinates 1054674..1055408 (-) Length 245 a.a.

Antitoxin (Protein)


Gene name abiEi Uniprot ID A0A7Z7PN10
Locus tag EXZ29_RS04530 Protein ID WP_020863064.1
Coordinates 1055508..1056107 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXZ29_RS04510 1050970..1052547 - 1578 WP_020863062.1 dicarboxylate/amino acid:cation symporter -
EXZ29_RS04515 1052567..1053910 - 1344 WP_129868741.1 FAD-dependent oxidoreductase -
EXZ29_RS04520 1054128..1054628 + 501 WP_020863063.1 isochorismatase family protein -
EXZ29_RS04525 1054674..1055408 - 735 WP_080511208.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
EXZ29_RS04530 1055508..1056107 - 600 WP_020863064.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
EXZ29_RS04535 1056375..1056494 + 120 Protein_835 isochorismatase family protein -
EXZ29_RS04540 1056684..1058018 + 1335 WP_020863065.1 DUF285 domain-containing protein -
EXZ29_RS04775 1058268..1059491 + 1224 WP_020863066.1 phosphatase PAP2 family protein -
EXZ29_RS04555 1059622..1060827 + 1206 WP_020863067.1 phosphatase PAP2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(4-210)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(5-53)


Sequences

Toxin        


Download         Length: 245 a.a.        Molecular weight: 28915.65 Da        Isoelectric Point: 9.5052

>T292674 WP_080511208.1 NZ_LS483501:c1055408-1054674 [Mycoplasma mycoides subsp. capri]
MKKISKNKDKINIIFKGGFLLSNIIGIKERTTKDIDYLLNNIVFSPDRIKELFEDILDYKKGDKIHFQIQKINEIKKKEK
YTGFRITVECKLDEIVEIIKIDVATGDIITSCQVRYNIENIFHNNSFYVYGYNLETMLAEKIHAIKELSLFNTRTKDFYD
IYLIYNLKRDDIDYMTLKNACINTFKQRNSIFDKDDLLELLNKIKNSQSTHNLTKQKNIYFYNKNIDFKFIIQSIIELIK
NIK

Download         Length: 735 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 23847.67 Da        Isoelectric Point: 8.3457

>AT292674 WP_020863064.1 NZ_LS483501:c1056107-1055508 [Mycoplasma mycoides subsp. capri]
MNYVEKIKEKAIQNNGLITRKEIISLKIPPIYITRMVRKKELEKIDIGIYALTSLDNYPYDPEFNFCSRYQVPVFSYVYA
LNLFDFTDVIPLNFEVTVYKGYNAHNLKPNTIVHYVNKEIFNLGITEIRNAFGNWVRTYDIERTICDLIKNRKNINVELF
VKTMNNYVNYEKKDWNKLYEYAEKMHIEKELVEIFQLII

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7PN10

References