Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3740593..3741410 Replicon chromosome
Accession NZ_LS483498
Organism Morganella morganii strain NCTC12028

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A2C5TM43
Locus tag DQM84_RS18060 Protein ID WP_004236532.1
Coordinates 3740593..3741075 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag DQM84_RS18065 Protein ID WP_004236533.1
Coordinates 3741102..3741410 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM84_RS18030 3735957..3736580 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
DQM84_RS18035 3736599..3737594 - 996 WP_004236526.1 serine/threonine protein kinase -
DQM84_RS18040 3737594..3737863 - 270 WP_004240741.1 YihD family protein -
DQM84_RS18045 3738066..3739181 + 1116 WP_004236528.1 molybdenum cofactor guanylyltransferase MobA -
DQM84_RS18050 3739391..3739693 + 303 WP_004236529.1 ABC transporter substrate-binding protein -
DQM84_RS18055 3739821..3740342 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
DQM84_RS19145 3740339..3740479 + 141 WP_004236531.1 hypothetical protein -
DQM84_RS18060 3740593..3741075 - 483 WP_004236532.1 GNAT family N-acetyltransferase Toxin
DQM84_RS18065 3741102..3741410 - 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
DQM84_RS18070 3741542..3742894 - 1353 WP_004236534.1 glutathione-disulfide reductase -
DQM84_RS18075 3742964..3743806 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
DQM84_RS18080 3743996..3744385 + 390 WP_004236536.1 DUF1090 domain-containing protein -
DQM84_RS18085 3744797..3745789 + 993 WP_004236539.1 inner membrane protein YhjD -
DQM84_RS18090 3745897..3746103 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(36-135)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17729.48 Da        Isoelectric Point: 10.2370

>T292668 WP_004236532.1 NZ_LS483498:c3741075-3740593 [Morganella morganii]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Download         Length: 483 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT292668 WP_004236533.1 NZ_LS483498:c3741410-3741102 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C5TM43

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References