Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 905950..906576 Replicon chromosome
Accession NZ_LS483498
Organism Morganella morganii strain NCTC12028

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag DQM84_RS04225 Protein ID WP_024474604.1
Coordinates 905950..906153 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag DQM84_RS04230 Protein ID WP_004236473.1
Coordinates 906217..906576 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM84_RS04205 902506..902844 + 339 WP_004236467.1 P-II family nitrogen regulator -
DQM84_RS04210 902864..904153 + 1290 WP_015422958.1 ammonium transporter AmtB -
DQM84_RS04215 904214..905077 - 864 WP_004236469.1 acyl-CoA thioesterase II -
DQM84_RS04225 905950..906153 - 204 WP_024474604.1 hemolysin expression modulator Hha Toxin
DQM84_RS04230 906217..906576 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
DQM84_RS04235 907139..910315 - 3177 WP_015422956.1 multidrug efflux RND transporter permease subunit -
DQM84_RS04240 910330..911526 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T292667 WP_024474604.1 NZ_LS483498:c906153-905950 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT292667 WP_004236473.1 NZ_LS483498:c906576-906217 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References