Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1523092..1523627 Replicon chromosome
Accession NZ_LS483496
Organism Haemophilus influenzae strain NCTC8455

Toxin (Protein)


Gene name relE Uniprot ID A0A852PXV4
Locus tag DQL17_RS07550 Protein ID WP_061671384.1
Coordinates 1523092..1523355 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DQL17_RS07555 Protein ID WP_111689109.1
Coordinates 1523352..1523627 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL17_RS09275 1518784..1518957 - 174 WP_005657572.1 DUF5363 domain-containing protein -
DQL17_RS07535 1518954..1520924 - 1971 WP_111689108.1 tRNA(Met) cytidine acetyltransferase TmcA -
DQL17_RS07540 1520929..1521270 - 342 WP_050846956.1 SirB2 family protein -
DQL17_RS07545 1521332..1522997 - 1666 Protein_1421 energy-dependent translational throttle protein EttA -
DQL17_RS07550 1523092..1523355 - 264 WP_061671384.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DQL17_RS07555 1523352..1523627 - 276 WP_111689109.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQL17_RS07560 1523979..1524599 + 621 WP_050848568.1 zinc transporter binding subunit ZevA -
DQL17_RS07565 1524602..1525576 + 975 WP_111689110.1 zinc transporter permease subunit ZevB -
DQL17_RS07570 1525764..1526393 - 630 Protein_1426 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-87)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10215.93 Da        Isoelectric Point: 7.8978

>T292665 WP_061671384.1 NZ_LS483496:c1523355-1523092 [Haemophilus influenzae]
MISVSGEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLN
THSEIFG

Download         Length: 264 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10358.94 Da        Isoelectric Point: 6.4800

>AT292665 WP_111689109.1 NZ_LS483496:c1523627-1523352 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHRHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A852PXV4

Antitoxin

Source ID Structure

References