Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 689347..689984 Replicon chromosome
Accession NZ_LS483496
Organism Haemophilus influenzae strain NCTC8455

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A121YHB9
Locus tag DQL17_RS03530 Protein ID WP_021035685.1
Coordinates 689580..689984 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag DQL17_RS03525 Protein ID WP_005656316.1
Coordinates 689347..689583 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL17_RS03500 684724..685464 - 741 WP_005662961.1 YebC/PmpR family DNA-binding transcriptional regulator -
DQL17_RS03505 685477..685950 - 474 WP_050948992.1 dihydroneopterin triphosphate diphosphatase -
DQL17_RS03510 685972..687738 - 1767 WP_050948993.1 aspartate--tRNA ligase -
DQL17_RS03515 687957..688475 + 519 WP_005688985.1 isoprenylcysteine carboxyl methyltransferase family protein -
DQL17_RS03520 688529..689254 + 726 WP_111688884.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
DQL17_RS03525 689347..689583 + 237 WP_005656316.1 antitoxin Antitoxin
DQL17_RS03530 689580..689984 + 405 WP_021035685.1 type II toxin-antitoxin system VapC family toxin Toxin
DQL17_RS03535 690051..690458 + 408 WP_005688980.1 lactoylglutathione lyase -
DQL17_RS03540 690532..691221 + 690 WP_021035684.1 ribonuclease T -
DQL17_RS03545 691535..692887 + 1353 WP_050948995.1 Na+/H+ antiporter family protein -
DQL17_RS03550 692919..693503 + 585 WP_050948996.1 primosomal replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15690.26 Da        Isoelectric Point: 8.9777

>T292664 WP_021035685.1 NZ_LS483496:689580-689984 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT292664 WP_005656316.1 NZ_LS483496:689347-689583 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A121YHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References