Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 330451..330922 Replicon chromosome
Accession NZ_LS483496
Organism Haemophilus influenzae strain NCTC8455

Toxin (Protein)


Gene name toxT Uniprot ID A0A806DTA9
Locus tag DQL17_RS01640 Protein ID WP_005654546.1
Coordinates 330451..330633 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag DQL17_RS01645 Protein ID WP_005650837.1
Coordinates 330626..330922 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL17_RS01625 326611..326832 - 222 WP_111688800.1 ABC transporter -
DQL17_RS01635 327275..330181 + 2907 WP_172452339.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DQL17_RS01640 330451..330633 + 183 WP_005654546.1 shikimate 5-dehydrogenase Toxin
DQL17_RS01645 330626..330922 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
DQL17_RS01650 331079..332995 + 1917 WP_111688801.1 ABC transporter ATP-binding protein -
DQL17_RS01655 333005..333541 + 537 WP_042601037.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
DQL17_RS01660 333557..334108 + 552 WP_111688802.1 Sua5/YciO/YrdC/YwlC family protein -
DQL17_RS01665 334112..334930 + 819 WP_111688803.1 shikimate dehydrogenase -
DQL17_RS01670 334927..335484 + 558 WP_050949054.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7318.33 Da        Isoelectric Point: 6.3057

>T292663 WP_005654546.1 NZ_LS483496:330451-330633 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Download         Length: 183 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT292663 WP_005650837.1 NZ_LS483496:330626-330922 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DTA9

Antitoxin

Source ID Structure

References