Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 245309..245913 Replicon chromosome
Accession NZ_LS483496
Organism Haemophilus influenzae strain NCTC8455

Toxin (Protein)


Gene name relE Uniprot ID A0A837MVY4
Locus tag DQL17_RS01235 Protein ID WP_050846512.1
Coordinates 245605..245913 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag DQL17_RS01230 Protein ID WP_005692346.1
Coordinates 245309..245605 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL17_RS01215 241075..242460 + 1386 WP_075985656.1 L-seryl-tRNA(Sec) selenium transferase -
DQL17_RS01220 242457..244316 + 1860 WP_075985657.1 selenocysteine-specific translation elongation factor -
DQL17_RS01225 244335..245189 + 855 WP_075985658.1 DUF3298 domain-containing protein -
DQL17_RS01230 245309..245605 + 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQL17_RS01235 245605..245913 + 309 WP_050846512.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DQL17_RS01240 245972..249088 - 3117 WP_111688773.1 TonB-dependent receptor -
DQL17_RS01245 249418..250716 + 1299 WP_075985659.1 trigger factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11920.68 Da        Isoelectric Point: 7.8657

>T292661 WP_050846512.1 NZ_LS483496:245605-245913 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT292661 WP_005692346.1 NZ_LS483496:245309-245605 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837MVY4

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References