292660

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 179943..180421 Replicon chromosome
Accession NZ_LS483496
Organism Haemophilus influenzae strain NCTC8455

Toxin (Protein)


Gene name VapD Uniprot ID A0A0K9L551
Locus tag DQL17_RS00935 Protein ID WP_050848517.1
Coordinates 179943..180221 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag DQL17_RS00940 Protein ID WP_012055040.1
Coordinates 180230..180421 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL17_RS00915 175131..176801 - 1671 WP_110430653.1 fructose-specific PTS transporter subunit EIIC -
DQL17_RS00920 176803..177744 - 942 WP_111688762.1 1-phosphofructokinase -
DQL17_RS00925 177746..179245 - 1500 WP_050948745.1 fused PTS fructose transporter subunit IIA/HPr protein -
DQL17_RS00930 179317..179847 - 531 WP_050948746.1 hypothetical protein -
DQL17_RS00935 179943..180221 - 279 WP_050848517.1 virulence-associated protein VapD Toxin
DQL17_RS00940 180230..180421 - 192 WP_012055040.1 DUF5397 family protein Antitoxin
DQL17_RS00945 180492..181790 - 1299 WP_074040071.1 hemolysin family protein -
DQL17_RS00950 181841..182365 - 525 WP_005669286.1 DUF1523 family protein -
DQL17_RS00955 182392..183174 - 783 WP_111688763.1 YchF/TatD family DNA exonuclease -
DQL17_RS00960 183213..184193 - 981 WP_050948750.1 DNA polymerase III subunit delta' -
DQL17_RS00965 184190..184822 - 633 WP_050948790.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10604.98 Da        Isoelectric Point: 5.7408

>T292660 WP_050848517.1 NZ_LS483496:c180221-179943 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNSLKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT292660 WP_012055040.1 NZ_LS483496:c180421-180230 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9L551

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References