Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1613467..1613996 Replicon chromosome
Accession NZ_LS483491
Organism Staphylococcus auricularis strain NCTC12101

Toxin (Protein)


Gene name mazF Uniprot ID A0A2K4C3I5
Locus tag DQL57_RS07645 Protein ID WP_059107861.1
Coordinates 1613467..1613829 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K4C4W9
Locus tag DQL57_RS07650 Protein ID WP_059107862.1
Coordinates 1613826..1613996 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL57_RS07625 1610377..1611147 - 771 WP_059107857.1 RNA polymerase sigma factor SigB -
DQL57_RS07630 1611122..1611601 - 480 WP_059107858.1 anti-sigma B factor RsbW -
DQL57_RS07635 1611603..1611929 - 327 WP_059107859.1 anti-sigma factor antagonist -
DQL57_RS07640 1612006..1613007 - 1002 WP_059107860.1 PP2C family protein-serine/threonine phosphatase -
DQL57_RS07645 1613467..1613829 - 363 WP_059107861.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL57_RS07650 1613826..1613996 - 171 WP_059107862.1 hypothetical protein Antitoxin
DQL57_RS07655 1614087..1615235 - 1149 WP_059107863.1 alanine racemase -
DQL57_RS07660 1615585..1615944 - 360 WP_059107864.1 holo-ACP synthase -
DQL57_RS07665 1616002..1616754 - 753 WP_059107865.1 PH domain-containing protein -
DQL57_RS07670 1616747..1618255 - 1509 WP_059107866.1 PH domain-containing protein -
DQL57_RS07675 1618248..1618727 - 480 WP_059107867.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13664.98 Da        Isoelectric Point: 10.2885

>T292654 WP_059107861.1 NZ_LS483491:c1613829-1613467 [Staphylococcus auricularis]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIDKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMEEVNRAIFISLGLHNMKHFKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6441.01 Da        Isoelectric Point: 4.0115

>AT292654 WP_059107862.1 NZ_LS483491:c1613996-1613826 [Staphylococcus auricularis]
MSNFNTTRYHNMEQILKEGYSQMADLNLSLATEAFPFECEACDCNESFLSSNHNNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4C3I5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4C4W9

References