Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1668621..1669210 Replicon chromosome
Accession NZ_LS483486
Organism Haemophilus influenzae strain NCTC12194

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag DQL18_RS08550 Protein ID WP_005653200.1
Coordinates 1668962..1669210 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag DQL18_RS08545 Protein ID WP_005653201.1
Coordinates 1668621..1668965 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL18_RS08530 1663847..1665238 - 1392 WP_111722585.1 sodium-coupled multidrug efflux MATE transporter HmrM -
DQL18_RS08535 1665282..1665896 + 615 WP_050829205.1 riboflavin synthase -
DQL18_RS08540 1665968..1668577 - 2610 WP_111722587.1 aminopeptidase N -
DQL18_RS08545 1668621..1668965 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQL18_RS08550 1668962..1669210 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
DQL18_RS08555 1669381..1669875 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
DQL18_RS08560 1669945..1671033 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
DQL18_RS08565 1671173..1672363 + 1191 WP_042594481.1 aspartate/tyrosine/aromatic aminotransferase -
DQL18_RS08570 1672522..1673139 - 618 WP_010869260.1 energy-coupling factor ABC transporter ATP-binding protein -
DQL18_RS08575 1673141..1673773 - 633 WP_005660550.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T292651 WP_005653200.1 NZ_LS483486:c1669210-1668962 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT292651 WP_005653201.1 NZ_LS483486:c1668965-1668621 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References