Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 744491..745128 Replicon chromosome
Accession NZ_LS483486
Organism Haemophilus influenzae strain NCTC12194

Toxin (Protein)


Gene name VapC1 Uniprot ID E4QWH2
Locus tag DQL18_RS03905 Protein ID WP_005649049.1
Coordinates 744491..744895 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID E4QWH3
Locus tag DQL18_RS03910 Protein ID WP_005649046.1
Coordinates 744892..745128 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL18_RS03875 740045..740611 + 567 WP_005544066.1 elongation factor P -
DQL18_RS03885 740968..741555 - 588 WP_005654063.1 primosomal replication protein -
DQL18_RS03890 741588..742940 - 1353 WP_105905462.1 Na+/H+ antiporter family protein -
DQL18_RS03895 743254..743943 - 690 WP_011271988.1 ribonuclease T -
DQL18_RS03900 744017..744424 - 408 WP_005688980.1 lactoylglutathione lyase -
DQL18_RS03905 744491..744895 - 405 WP_005649049.1 type II toxin-antitoxin system VapC family toxin Toxin
DQL18_RS03910 744892..745128 - 237 WP_005649046.1 antitoxin Antitoxin
DQL18_RS03915 745221..745946 - 726 WP_011271987.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
DQL18_RS03920 745999..746517 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
DQL18_RS03925 746736..748502 + 1767 WP_042594297.1 aspartate--tRNA ligase -
DQL18_RS03930 748524..748997 + 474 WP_011271985.1 dihydroneopterin triphosphate diphosphatase -
DQL18_RS03935 749009..749749 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15692.29 Da        Isoelectric Point: 8.9777

>T292648 WP_005649049.1 NZ_LS483486:c744895-744491 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9037.19 Da        Isoelectric Point: 4.2342

>AT292648 WP_005649046.1 NZ_LS483486:c745128-744892 [Haemophilus influenzae]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E4QWH2

Antitoxin

Source ID Structure
AlphaFold DB E4QWH3

References